Research

Our goals are to develop, validate and translate novel imaging techniques for better understanding and treatment of cardiovascular disease.

Current Studies and Trials

Actively recruiting:

  • Due to reorganization of parts of our research strategy and a new funding period we are currently not actively recruiting new participants.

Recruitment finished, follow-up phase:

Key Publications by Topic

COVID-19 Cardiac Involvement

  • Puntmann VO, Carerj ML, Wieters I, Fahim M, Arendt C, Hoffmann J, Shchendrygina A, Escher F, Vasa-Nicotera M, Zeiher AM, Vehreschild M, Nagel E. Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19). JAMA Cardiol 2020;5(11):1265-1273. DOI — Impression COVID Study

  • Puntmann VO, Martin S, Engel O, et al. Long-term cardiac pathology in individuals with mild initial COVID-19 illness. Nat Med 2022. DOI

T1/T2 Mapping and Tissue Characterization

  • Puntmann VO, Peker E, Chandrashekhar Y, Nagel E. T1-Mapping and Outcome in Nonischemic Cardiomyopathy: All-Cause Mortality and Heart Failure. JACC Cardiovasc Imaging 2016;9(1):40-50. DOI

  • Dabir D, Child N, Puntmann VO, Nagel E et al. Reference values for healthy human myocardium using a T1 mapping methodology: results from the International T1 Multicenter cardiovascular magnetic resonance study. J Cardiovasc Magn Reson 2014;16:69. DOI

  • Puntmann VO, Voigt T, Chen Z, Nagel E et al. T1 Mapping in Discrimination of Hypertrophic Phenotypes: Hypertensive Heart Disease and Hypertrophic Cardiomyopathy. Circ Cardiovasc Imaging 2015;8:e003285.

Ischemia and Coronary Artery Disease

  • Nagel E et al. Magnetic Resonance Perfusion or Fractional Flow Reserve in Coronary Disease. N Engl J Med 2019;380:2418-2428. DOI — The MR-INFORM Trial

  • Nagel E et al. Noninvasive Diagnosis of Ischemia-Induced Wall Motion Abnormalities With the Use of High-Dose Dobutamine Stress MRI. Circulation 1999;99:763-770.

  • Kim et al. Magnetic Resonance Coronary Angiography for the Detection of Coronary Stenoses. N Engl J Med 2001;345:1863-1869.

Heart Failure (HFpEF)

  • DECIPHER HFpEF study — First multicentre study on CMR-based diagnosis of heart failure with preserved ejection fraction. Study details

Standardization and Guidelines

  • Kramer CM, Barkhausen J, Flamm SD, Kim RJ, Nagel E. Standardized cardiovascular magnetic resonance (CMR) protocols 2013 update. J Cardiovasc Magn Reson 2013;15:91. DOI

  • Schulz-Menger J, Bluemke DA, Nagel E et al. Standardized image interpretation and post-processing in cardiovascular magnetic resonance. J Cardiovasc Magn Reson 2020;22:19.

  • Messroghli DR, Moon JC, Ferreira VM, et al. Clinical recommendations for cardiovascular magnetic resonance mapping of T1, T2, T2* and extracellular volume. J Cardiovasc Magn Reson 2017;19:75. DOI

Our Partnerships

We are supported by the German Centre for Cardiovascular Research (www.dzhk.de).